液滴微流控芯片合成单分散PEG水凝胶微球及其粒径调控

Synthesis of Monodisperse PEG Hydrogel Microball Using a Droplet Microfluidic Chip and Its Size Control

摘要: 利用液滴微流控技术制备了单分散的微米级聚乙二醇（PEG）水凝胶微球。首先利用流动聚焦型微流控芯片产生单分散的水凝胶微液滴，然后经过紫外光原位引发聚合形成水凝胶微球，系统考察了PEG质量分数、表面活性剂加入量、连续相流速等影响因素，在优化的实验条件下得到了粒径为115 μm、单分散性较好的PEG凝胶微球。

Abstract: The monodisperse PEG hydrogel microballs were prepared by droplet microfluidic chip. First, monodisperse microdroplets of PEG hydrogel were successfully prepared in the microfluidic flow focusing chip. Then, the microdroplets of PEG hydrogel were cured by UV irradiation in situ. Various experimental conditions pertaining to the concentration of PEG hydrogel solution and surfactant, flow rates of continuous phases were investigated. The prepared PEG hydrogel microballs were nearly monosized with a diameter of 115 μm under optimal conditions.