(+)-4-(2-甲基丁基)-4′-氰基联苯的合成

Synthesis of ( + ) -4- (2-Methylbutyl) -4''''-Cyanobiphenyl (CB- 15)

摘要: 以(+)-对甲苯磺酸-2-甲基丁酯与联苯基溴化镁反应,在催化剂作用下实现手性戊基与联苯偶联,再经碘化和氰化,合成了(+)-4-(2-甲基丁基)-4′-氰基联苯(CB-15)。总收率为15%(以左旋戊醇计算)。同时,就手性戊基与联笨偶联的机理等问题作了讨论。

Abstract: CB-15 was prepared from ( + )-2-methylbutyl-p-toluenesulfonate by Grignard reaction, Iodation and cyanation. The yield is 15%. The mechanism of substitution reaction between ( + )-2-methylbutyl-p-toluenesulfonate with biphenyl magnasium bromide was also discussed.