Abstract: The study of refined separation of fluid catalytic cracking (FCC) gasoline fractions is an important means to reduce the benzene content in gasoline. Owing to the high benzene content in the middle fraction of FCC gasoline, separating FCC gasoline into light, middle, and heavy fractions enables effective separation of benzene and non-benzene components to meet the requirements for benzene content in the VIB standard for automotive gasoline. The separation technology that uses a distillation column or a stripping column to separate gasoline is a commonly used technique, but it has problems such as a complex process, high reflux ratio, and high energy consumption. In this work, based on the existing stripping column for removing benzene from FCC gasoline in a catalytic cracking unit of a Sinopec refinery, the benzene removal performance of the stripping column scheme is studied through simulation and optimization using Aspen software, and the distillation column scheme is investigated under the same feed conditions. A comparison of the two processes for separating benzene—stripping column and distillation column—is presented. The technical performance is systematically evaluated. The results show that using distillation-based separation and benzene-removal technology to treat FCC gasoline reduces the volume fraction of benzene from 1.15% to below 0.7%; the reflux ratio and energy consumption are 0.45 and 5.486 kg of standard oil per ton of gasoline lower, respectively, than those of the stripping column scheme. The distillation method has more advantages in separation accuracy, energy consumption control, and benzene removal efficiency. This work can provide guidance for refineries to solve the problem of excessive benzene content in gasoline.