Abstract: The experimental values of saturation vapor pressure, liquid volume, and enthalpy of vaporization for 18 classes of 382 substances were used to evaluate the predictive ability of the RK, SRK, PR, and PC-SAFT equations of state (EoS) for thermodynamic properties. The average relative deviations of the four EoS were obtained by comparing with the experimental data, and the accuracy of the four EoS in predicting the thermodynamic properties of the 18 classes of substances was evaluated. The results show that the PC-SAFT EoS has the most accurate predictions for the enthalpy of vaporization, saturation vapor pressure, and liquid volume, with average relative deviations of 1.57%, 1.20%, and 0.99%, respectively. The average relative deviations of the PR and SRK EoS for the enthalpy of vaporization are 2.57% and 2.68%, respectively, and those for the saturation vapor pressure are 1.47% and 1.80%, respectively. Furthermore, the average relative deviations of the two EoS for liquid volume are much larger than those of the PC-SAFT EoS. The average relative deviations of the RK EoS for all three thermodynamic properties are all greater than 18.00%. For the prediction of thermodynamic properties of organic substances, especially for associating substances, the PC-SAFT EoS should be preferred.