Abstract: This paper studies the removal of trace metal ions in isopropanol. Sodium-type ion-exchange resin used in the industry is subjected sequentially to acid, alkali and then acid treatment for hydrogenation. Then, the isothermal and kinetic adsorption of Na⁺ and K⁺ by the resin in isopropanol was studied by static adsorption experiments. The isothermal adsorption obtained by origin fitting conforms to the langmuir isothermal adsorption model, and the kinetics adsorption conforms to the pseudo-first-order kinetic model. The maximum adsorption capacities of Na⁺ and K⁺ in isopropanol were calculated to be 4.28 mg/g and 3.36 mg/g, respectively. The breakthrough curves of Na⁺ and K⁺ were obtained by dynamic experiments. The adsorption process was simulated, and an adsorption physical model ignoring pressure drop and temperature change was established. The dynamic adsorption process of Na⁺ and K⁺ in isopropanol was simulated by Aspen Adsorption, and the simulation results were in good agreement with the experimental breakthrough curves. Using the ion-exchange resin, the content of metal ions in isopropanol was detetmined to be less than 5.00 μg/L. These results provide a basis for the design of adsorption materials and devices for trace metal ions in isopropanol. In addition, a method of slowly digesting the resin with nitric acid and hydrogen peroxide in a heated environment was proposed. This method can detect the content of metal ions in the resin, and the error between the detection result and the actual value is within 10%.