Nanostructure Controlled by Flash Nanoprecipitation and Application on Agriculture
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摘要: 农药的减量增效是近年来农药领域的关键问题，使用纳米载体技术将农药制成纳米农药为解决这一难题提供了新思路。不同于大多数基于热力学平衡组装的纳米载体技术，新兴的瞬时纳米沉淀法基于动力学控制原理、通过化学工程上的流体湍流混合制备纳米材料。这种方法不仅具有载药率高、制备时间短、易于放大与连续化等特点，还可以系统地调控纳米微观结构，如形貌、内部结构、表面结构等，为纳米材料在农药上进一步的高效和低毒利用提供帮助。Abstract: The pesticide reducing has been a key issue in pesticides area in recent years. The use of nano-carrier technology to incorporate pesticides into nanoparticle provides new route for solving the problem. Different from most nano-carrier technologies which are based on thermodynamic equilibrium self-assembly, the emerging Flash Nanoprecipitation (FNP) method is based on kinetic control, preparing nanoparticles through turbulent mixing of chemical engineering fluids. It has advantages like high drug loading efficiency, short preparation time (milliseconds), easy to scale-up and continuously production, etc. Moreover, it could also systematically control the microstructures of nanoparticle, such as morphology, internal structure and surface structure, which could provide help for further improving the efficiency and low-toxic utilization of pesticide nanoparticle.
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Key words:
- Flash Nanoprecipitation /
- Pesticide Nanoparticle /
- Microstructure /
- Fluid Mixing
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表 1 用于调控纳米粒子微观结构的两亲性嵌段聚合物
Table 1. Diblock copolymer used for controlling the nanostructure
Block Copolymer Full Name of Block Copolymer Molecular Structure PEG-b-PCL Polyethylene Glycol-b- Polycaprolactone 
PEG-b-PLA Polyethylene Glycol-b- Polylactide 
PEG-b-PLGA Polyethylene Glycol-b-Poly (lactic-co-glycolic acid) 
Dextran-b-PCL Dextran-b-Polycaprolactone 
Dextran-b-PLA Dextran-b-Polylactide 
Dextran-b-PLGA Dextran-b-Poly (lactic-co-glycolic acid) 
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