瞬时纳米沉淀法调控纳米结构及其在农业上的应用

王铭纬; 俞洁; 赵洪阳; 付智楠; 陈凯; 王俊有; 徐益升; MartienA. Cohen Stuart; 郭旭虹

doi:10.14135/j.cnki.1006-3080.20200929002

瞬时纳米沉淀法调控纳米结构及其在农业上的应用

doi: 10.14135/j.cnki.1006-3080.20200929002

华东理工大学化工学院，上海 200237

基金项目: 国家自然科学基金青年基金（21706074）

详细信息

作者简介:
王铭纬（1989—），男，河南人，博士，讲师，主要研究方向为瞬时纳米沉淀法调控纳米结构。E-mail：mingweiwang@ecust.edu.cn

通讯作者:
郭旭虹，E-mail：guoxuhong@ecust.edu.cn

中图分类号: TQ317.9
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出版历程
- 收稿日期: 2020-09-29
- 网络出版日期: 2021-01-07

Nanostructure Controlled by Flash Nanoprecipitation and Application on Agriculture

School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China

摘要

摘要: 农药的减量增效是近年来农药领域的关键问题，使用纳米载体技术将农药制成纳米农药为解决这一难题提供了新思路。不同于大多数基于热力学平衡组装的纳米载体技术，新兴的瞬时纳米沉淀法基于动力学控制原理、通过化学工程上的流体湍流混合方式制备纳米材料。这种方法不仅具有载药率高、制备时间短、易于放大与连续化生产等特点，还可以系统地调控纳米微观结构，如形貌、内部结构、表面结构等，为纳米材料在农药领域进一步的高效和低毒利用提供帮助。本文综述了瞬时纳米沉淀法在纳米结构调控及农业上的应用。
- 瞬时纳米沉淀法 /
- 纳米农药 /
- 微观结构 /
- 流体混合
Abstract: The pesticide reducing has been a key issue in pesticides area in recent years. The use of nano-carrier technology to incorporate pesticides into nanoparticle provides new route for solving the problem. Different from most nano-carrier technologies which are based on thermodynamic equilibrium self-assembly, the emerging Flash Nanoprecipitation (FNP) method is based on kinetic control, preparing nanoparticles through turbulent mixing of chemical engineering fluids. It has advantages like high drug loading efficiency, short preparation time (milliseconds), easy to scale-up and continuously production, etc. Moreover, it can also systematically control the microstructures of nanoparticle, such as morphology, internal structure and surface structure, which can provide help for further improving the efficiency and low-toxic utilization of pesticide nanoparticle.
- flash nanoprecipitation /
- nano-pesticide /
- microstructure /
- fluid mixing

HTML全文

图 1 封闭撞击流混合器（CIJ）（a），多通道涡流混合器（MIVM）（b）和适用于大流量的MIVM （c）^{[19, 40]}

Figure 1. Confined Impinging Jets (CIJ) (a), Multi-Inlet Vortex Mixer (MIVM) (b) and MIVM for higher flow rate (c)^{[19, 40]}

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图 2 FNP法制备纳米粒子示意图

Figure 2. Illustration of nanoparticle preparation by FNP

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图 3 逆向FNP包载亲水性溶质^[43]

Figure 3. iFNP encapsulates water-soluble solute^[43]

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图 4 FNP法调控纳米粒子的形貌（a）和内部结构（b）^[44-45]

Figure 4. Morphology (a) and internal structure (b) controlled by FNP^[44-45]

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图 5 FNP法制备聚合物微球（a），Janus纳米粒子（b）和聚电解质纳米粒子（c）^{[46, 50, 58]}

Figure 5. Polymer colloid (a), Janus nanoparticle (b) and polyelectrolyte nanoparticle prepared by FNP (c)^{[46, 50, 58]}

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图 6 表面修饰有叶酸基团的纳米粒子^[62]

Figure 6. Nanoparticle modified with folic group on surface^[62]

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图 7 FNP法制备不同形貌负载阿维菌素（a）和负载λ-氯氟氰菊酯载药纳米粒子及其应用（b）^[64-66]

Figure 7. Schematic illustrating the FNP method for preparing abamectin-loaded (a) and λ-cyhalothrin-loaded nanoparticles and bioassay (b)^[64-66]

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表 1 用于调控纳米粒子微观结构的两亲性嵌段聚合物

Table 1. Diblock copolymer used for controlling the nanostructure

Block copolymer	Full name of block copolymer	Molecular structure
PEG-b-PCL	Polyethylene glycol-b- polycaprolactone
PEG-b-PLA	Polyethylene glycol-b- polylactide
PEG-b-PLGA	Polyethylene glycol-b-poly (lactic-co-glycolic acid)
Dextran-b-PCL	Dextran-b-polycaprolactone
Dextran-b-PLA	Dextran-b-polylactide
Dextran-b-PLGA	Dextran-b-poly (lactic-co-glycolic acid)

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