Abstract:
Bacterial infection has been one of the major health threats to modern human beings. Effective as they are, the traditional antibiotics are also easy to cause bacterial drug-resistance, thereby leading to the extensive development of advanced functional materials with photodynamic/photothermal and drug-loading properties. To endow the materials with targeting effects to improve the therapeutic efficiency, it is important to introduce a targeting moiety during the construction of antibacterial systems. Carbohydrates are commonly used as targeting agents, because they can not only target corresponding lectins on bacteria but also significantly enhance the biocompatibility of materials. Here, a galactose-conjugated perylenediimide was loaded onto 2D MoS
2 platform through π-π stacking. Moreover, the antibiotic ceftazidime was encapsulated to form a
Pseudomonas aeruginosa -targeted therapeutic system. Perylenediimide, as a photosensitizer, could produce reactive oxygen species upon light irradiation for photodynamic therapy, which further realized combinning chemo- and photodynamic therapy on
Pseudomonas aeruginosa. This complexed system significantly reduces the dose of antibiotics, diminishes drug-resisting effects and provides new therapeutic insights for clinical-chronic bacteria.