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一种高稳定性钆类核磁共振成像造影剂的合成

    通讯作者: 胡爱国, hagmhsn@ecust.edu.cn
  • 基金项目: 国家自然科学基金(21274042)

Synthesis of a Highly Stable Gadolinium Based MRI Contrast Agent

    Corresponding author: HU Ai-guo, hagmhsn@ecust.edu.cn
  • 摘要: 合成了一种基于氮氧化二乙烯三胺五乙酸(DTPA)二异丙胺双酰胺的钆配合物,兼具高弛豫率和高稳定性。通过高分辨质谱、核磁谱图确认了氮氧化配体及对应的钆配合物的结构,并通过电位滴定法测得其配位稳定性常数。实验结果表明此配合物的水合常数为3,弛豫率(16.39 mM-1·s-1)达到商用造影剂的3倍,稳定性优于商用造影剂Gd-DTPA-BMA(Omniscan®)且表现出良好的成像效果以及优异的生物相容性,具有投入临床应用的巨大潜力。
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出版历程
  • 收稿日期:  2017-04-07
  • 刊出日期:  2018-04-22

一种高稳定性钆类核磁共振成像造影剂的合成

    通讯作者: 胡爱国, hagmhsn@ecust.edu.cn
  • 1. 华东理工大学材料科学与工程学院, 上海市先进聚合物材料重点实验室, 上海 200237
基金项目:  国家自然科学基金(21274042)

摘要: 合成了一种基于氮氧化二乙烯三胺五乙酸(DTPA)二异丙胺双酰胺的钆配合物,兼具高弛豫率和高稳定性。通过高分辨质谱、核磁谱图确认了氮氧化配体及对应的钆配合物的结构,并通过电位滴定法测得其配位稳定性常数。实验结果表明此配合物的水合常数为3,弛豫率(16.39 mM-1·s-1)达到商用造影剂的3倍,稳定性优于商用造影剂Gd-DTPA-BMA(Omniscan®)且表现出良好的成像效果以及优异的生物相容性,具有投入临床应用的巨大潜力。

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