Abstract: Due to the problem of large power consumption of mine pump units during operation, a mathematical model is established to improve the operation efficiency of the pump units. In this model, the total flow, single pump flow rate and numbers of open pump sets are chosen as the constraint conditions of the mathematical model, the ratio of the actual flow rate is chosen as the variable independent, while the minimum total input power of the dynamos is treated as the objective function of the operational model of the pump units. Genetic algorithms are used to optimize the operation mode of the pump units in order to make the pump units operate economically and reduce the inefficient pump adjustment.