Preparation of Salvianolic Acid B Poly(butylcyanoacrylate) Nano-Particles and Evaluation of Their in vitro Properties

Salvianolic acid B poly(butylcyanoacrylate) nanoparticles（Sal BPBCA NP） were prepared by emulsion polymerization method. Two formulations, T1P0 and T1P1, were prepared by coating surface of Sal B-PBCA NP using Tween 80 and PEG 20000. Drug release profiles from different formulations of Sal B-PBCANP, T1P0, T1P1 were determined. Results indicate that mean diameter, entrapment efficiency and drug loading of Sal BPBCA NP were 99.02 nm, 46.55% and 0.792%, respectively. It was found that the in vitro release of Sal BPBCA NP, T1P0 and T1P1 were accumulated up to (76.15±0.69)%, (63.72±1.80)% and (47.09±5.72)% over 48 h, respectively. The in vitro release properties could be expressed by the Weibull equation. Compared with Sal BPBCA NP without surface coating, formulation T1P1 obtained by coating surface of Sal B-PBCA NP using Tween 80 and PEG 20000 showed significant sustained release effect.