Preexpansion of Fine Griseofulvin Particle Formation by Rapid Expansion of Supercritical Solution

The pre expansion operation of rapid expansion of supercritical solution (RESS) is investigated by classical homogeneous nucleation theory in this article. Griseofulvin will not deposit from the supercritical CO 2 even though the supersaturation increases with the increasing pre expansion temperature. Otherwise, the lower pre expansion pressure results in higher nucleation rate. Therefore, high pre expansion temperature can be chosen when higher pre expansion pressure is set.