reparation and in Vitro pHSensitive Release of CMCTFA Modified Doxorubicin Nanoliposomes

Folatecoupled carboxymethyl chitosan(CMCTFA)was synthesized through the 1ethyl3(3dimethylaminopropyyl)carbodiimidemediated reaction. CMCTFA modified pHsensitive nanoliposomes were prepared by the filmpH gradient method using doxorubicin(DOX) as a model drug.The encapsulation efficiency, particle size distribution, ζ potential and drug release character of the nanoliposomes were investigated. The results showed that the ζ potential of CMCTFA modified DOX nanoliposomes decreased significantly compared with unmodified DOX nanoliposomes, while changed slightly in comparison with CMCT modified DOX nanoliposomes. The release rate and cumulative release amount of DOX from nanoliposomes in acidic condition increased significantly after CMCTFA modification.