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    WEI Jia, LI Yuan-yuan, LI Yi-xue, YU Fu-dong. Construction of Hemoglobin Degradation Pathway of Schistosoma and Analysis of Conserved Domains of Pathway Key Enzymes[J]. Journal of East China University of Science and Technology, 2011, (6): 706-714.
    Citation: WEI Jia, LI Yuan-yuan, LI Yi-xue, YU Fu-dong. Construction of Hemoglobin Degradation Pathway of Schistosoma and Analysis of Conserved Domains of Pathway Key Enzymes[J]. Journal of East China University of Science and Technology, 2011, (6): 706-714.

    Construction of Hemoglobin Degradation Pathway of Schistosoma and Analysis of Conserved Domains of Pathway Key Enzymes

    • On the basis of hemoglobin degradation pathway of Plasmodium falciparum, hemoglobin degradation pathways of Schistosoma japonicum and Schistosoma mansoni were constructed using bioinformatic methods. Sequences and structures of conserved domains of pathway key enzymes were analyzed after pathway construction. The catalytic sites of predicted hemoglobinases of Schistosoma are highly conserved with Plasmodium in both sequence and structure level. This paper provides a theoretical foundation for Schistosoma hemoglobinase study, and analysis of their interactions with substrates or inhibitors in threedimensional level.
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