Effect of Surface Modification on Protein Adsorption Characteristics of Hydroxyapatite

Hydroxyapatite (HAP) nanoparticles were surface grafted with poly(methyl methacrylate) (PMMA) through atom transfer radical polymerization (ATRP). As the amount of grafted PMMA increased, the dispersibility of surfacegrafted HAP (gHAP) in aqueous solution was improved. Bovine serum albumin (BSA) and lysozyme (LSZ) were selected as models to study their adsorption behaviors on HAP and gHAP. Our results showed that the adsorption capacity on gHAP was higher than that on HAP, indicating that the adsorptive property of HAP was improved due to surface modification of HAP with PMMA.