Preparation and Release Behavior of RapamycinLoaded Micelles

The Rapamycinloaded micelles with biodegradable dendrimer as drug carrier were prepared by dialysis method. Scanning electronic microscope(SEM), dynamic light scattering(DLS) and UV spectrophotometer were used to investigate morphology, size and in vitro release behavior. The results showed that the drug loaded micelle was a vesicle with hollow construction. The size of Rapamycinloaded micelles increased significantly, and the average drug content and encapsulation efficiency increased up to 40% and 91%, respectively. In vitro release results show that sustainedrelease is obvious. The firstorder Gompertz is the best model which can predict the true release of Rapamycin from drugloaded micelles in vitro release.