SU Yi-dong, WU Fan-hong *. Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d] cyclohepten-5-one[J]. Journal of East China University of Science and Technology, 2002, (6): 665-667.
Citation:
SU Yi-dong, WU Fan-hong *. Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d] cyclohepten-5-one[J]. Journal of East China University of Science and Technology, 2002, (6): 665-667.
SU Yi-dong, WU Fan-hong *. Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d] cyclohepten-5-one[J]. Journal of East China University of Science and Technology, 2002, (6): 665-667.
Citation:
SU Yi-dong, WU Fan-hong *. Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d] cyclohepten-5-one[J]. Journal of East China University of Science and Technology, 2002, (6): 665-667.
Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzoa,d cyclohepten-5-one
Chloro-10,11-dihydro-4-aza-5H-dibenzoa,dcyclohepten-5-one is an important intermediate of loratadine.It was synthesized from 2-cyano-3-methylpyridine as the starting material via Ritter reaction, alkylation, cyanidation, hydrolysis and cyclization under mild conditions. The total yield attained was 25.6%. The chemical structure was confirmed by means of 1 H-NMR,MS and m.p.data.
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