Relationship between LHβ, FSHβ Genes and Central Precocious Puberty in Chinese Girls Based on the Polymorphisms in the 5′-Flanking Regions

In this paper, four single nucleotide polymorphisms（LHβ-1424 C/G, LHβ-238 G/A, FSHβ-261 G/T, FSHβ-132 T/A） in the 5′-upstream regions of LHβ and FSHβ were found in 27 case samples by sequencing. And these four SNPs were genotyped in 283 chinese girls suffered central precocious puberty(CPP) and 284 normal girls. Results show that the association of four polymorphisms in the 5′-upstream regions of LHβand FSHβ with CPP is not significant (P>0.05). And there is no relationship between the CPP and the SNPs in the transcriptional regulation region of LHβ and FSHβ.