WANG Jian-jun, YANG Xue-yan, WU Fan-hong *. Improved Synthesis of Cetirizine Hydrochloride[J]. Journal of East China University of Science and Technology, 2002, (6): 668-670.
Citation:
WANG Jian-jun, YANG Xue-yan, WU Fan-hong *. Improved Synthesis of Cetirizine Hydrochloride[J]. Journal of East China University of Science and Technology, 2002, (6): 668-670.
WANG Jian-jun, YANG Xue-yan, WU Fan-hong *. Improved Synthesis of Cetirizine Hydrochloride[J]. Journal of East China University of Science and Technology, 2002, (6): 668-670.
Citation:
WANG Jian-jun, YANG Xue-yan, WU Fan-hong *. Improved Synthesis of Cetirizine Hydrochloride[J]. Journal of East China University of Science and Technology, 2002, (6): 668-670.
Chlorodiphenylbromomethane, prepared by the bromination following the Friedel-Crafts reaction of benzene with p-chlorobenzyl chloride, underwent the reaction sequences of two condensations, and salt formation with hydrochloric acid to obtain cetirizine hydrochloride with an overall yield of 29%.
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