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    SHI Zhu, LIU Qin, ZHANG Zhi-hui, YANG Min-jun, ZHANG Yuan-xing. Evaluation on Biosafety of Attenuated Vibrio anguillarumBased on Module Animal Zebrafish[J]. Journal of East China University of Science and Technology, 2011, (6): 722-726.
    Citation: SHI Zhu, LIU Qin, ZHANG Zhi-hui, YANG Min-jun, ZHANG Yuan-xing. Evaluation on Biosafety of Attenuated Vibrio anguillarumBased on Module Animal Zebrafish[J]. Journal of East China University of Science and Technology, 2011, (6): 722-726.
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    Evaluation on Biosafety of Attenuated Vibrio anguillarum Based on Module Animal Zebrafish

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    • It is getting more applicable to prevent cultivated fish from disease by vaccination. Fish can be protected by attenuated live vaccine through bath vaccination. Biosafety of the attenuated Vibrio anguillarum MVAV6203 was evaluated by using zebrafish as modle animal. We demonstrated that the Lethal Dose (LD50) of the attenuated live Vibrio anguillarum MVAV6203 to a zebrafish was 9.26×104 CFU by injection vaccination. When the initiated bacteria density was 1.0×106 CFU/mL, there was no bacteria detected after 10 d in water. No bacteria survived in zebrafish 3 d later after bath or injection vaccination. The attenuated Vibrio anguillarum MVM6203 is safe.
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