Investigation of Fluid Circulation and Oxygen Transfer in Animal Cell Culture Bioreactors

Fluid circulation and oxygen transfer process in Celligen bioreactor have been investigated in this paper. Fluid circulation is only related to the rotating rate of impeller during the scaling-up of the bioreactors demensionally. Oxygen transfer, on which the rotating rate of impeller has little effect, is obviously affected by the screen area of the impeller and degree of aeration, and their correlations have been presented.