Synthetic Process of Active Antimicrobial 5-Chloro-2-(4-Chloro-Phenoxy)-Phenol

This paper presents an improved process for the synthesis of 5-chloro-2-(4-chloro-phenoxy)-phenol by using 1,4-dichlorobenzene as a starting material,through acetylation,etherification,acetylperoxide oxidation and hydrolysis,the total yield reached 32.9%.Mesitylene instead of xylene,was used as solvent,and potassium hydroxide instead of potassium carbonate,was used to react with phenol to generate nucleophilic reagent during etherization,through which the yield reached 69.2%.During the acetylperoxide oxidation,with acetic acid as solvent,peracetiacid as oxidizing agent prepared through the reaction of acetic anhydride with hydrogen peroxide(w=0.30),the yield reached 72.7%.