Drug Delivery System Based on (6,5) Single-Walled Carbon Nanotube Loaded with Doxorubicin Hydrochloride

A drug delivery system was designed in this paper. The system was composed of (6,5) chiral single-walled carbon nanotube ((6,5)SWCNT), doxorubicin hydrochloride (Dox), human serum albumin (HSA), and folic acid (FA). Firstly, the Dox-HSA-FA was prepared and (6,5) SWCNT was isolated by aqueous two-phase extraction. Then, (6,5) SWCNT-Dox-HSA-FA was dispersed into Dox-HSA-FA by ultrasonication. Finally, cytotoxicity evaluation of the complex was performed using Hep G2 cells. The results showed that the IC₅₀ of Dox-HSA-FA and (6,5) SWCNT-Dox-HSA-FA was 27.3 μg/mL and 25.7 μg/mL, respectively. The results indicated that the targeting effect of Dox was enhanced in the (6,5) SWCNT-Dox-HSA-FA complex.