Halogen-Exchange Fluoridation Reaction of Aromatic Compounds Catalyzed by the Compatibility of Phase Transfer Catalysts

The halogen-exchange fluoridation reaction is an important approach to prepare aromatic fluorides,which has been widely applied in industrial production.The fluoridation reactions of single or multiple halogen substituted aromatic compounds were carried out with the complex phase transfer catalyst,Ph₄PBr/(x=5%) and 18-crown-6/(x=1%),affording the corresponding products in up to 92% yield.This method has the advantages such as low amount of catalyst and wide substrate scope.