Phosphoester Cross-Linked Elastomer with Graphene Oxide: Synthesis and Application as Drug Carrier

Based on a facile crosslinked reaction between diphosphoesters of polytetramethylene-oxide glycol (PTMEG1000-P) and diglycidyl ether of polyethylene glycol (PEG-E) prepared without any phase-transfer catalyst with graphene oxide (GO),a new series of degradable crosslinked phosphoester polymers (CPs) were prepared and characterized.The relevant experiments suggested good mechanical and degradable properties of the polymers.GO played an important role for the properties of CPs polymers,such as mechanical property and degradation rate.Drug release tests and biological cytotoxicity studies in vitro suggested that the polymers had great potential applications in drug delivery systems.