Abstract:
Folatecoupled carboxymethyl chitosan(CMCTFA)was synthesized through the 1ethyl3(3dimethylaminopropyyl)carbodiimidemediated reaction. CMCTFA modified pHsensitive nanoliposomes were prepared by the filmpH gradient method using doxorubicin(DOX) as a model drug.The encapsulation efficiency, particle size distribution, ζ potential and drug release character of the nanoliposomes were investigated. The results showed that the ζ potential of CMCTFA modified DOX nanoliposomes decreased significantly compared with unmodified DOX nanoliposomes, while changed slightly in comparison with CMCT modified DOX nanoliposomes. The release rate and cumulative release amount of DOX from nanoliposomes in acidic condition increased significantly after CMCTFA modification.