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    马俊, 李莉, 王铭纬, 周志明, 郭旭虹. 基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子[J]. 华东理工大学学报(自然科学版), 2017, (5): 597-605. DOI: 10.14135/j.cnki.1006-3080.2017.05.001
    引用本文: 马俊, 李莉, 王铭纬, 周志明, 郭旭虹. 基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子[J]. 华东理工大学学报(自然科学版), 2017, (5): 597-605. DOI: 10.14135/j.cnki.1006-3080.2017.05.001
    MA Jun, LI Li, WANG Ming-wei, ZHOU Zhi-ming, GUO Xu-hong. Preparation of Size-Controllable Drug Loaded Nano Particles Based on Flash Nano Precipitation Method[J]. Journal of East China University of Science and Technology, 2017, (5): 597-605. DOI: 10.14135/j.cnki.1006-3080.2017.05.001
    Citation: MA Jun, LI Li, WANG Ming-wei, ZHOU Zhi-ming, GUO Xu-hong. Preparation of Size-Controllable Drug Loaded Nano Particles Based on Flash Nano Precipitation Method[J]. Journal of East China University of Science and Technology, 2017, (5): 597-605. DOI: 10.14135/j.cnki.1006-3080.2017.05.001

    基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子

    Preparation of Size-Controllable Drug Loaded Nano Particles Based on Flash Nano Precipitation Method

    • 摘要: 合成了5种具有不同分子量、不同亲疏水链段比例的两亲性嵌段共聚物——甲氧基聚乙二醇-b-聚己内酯(mPEG-b-PCL),并以其为表面活性剂,采用瞬时纳米沉淀(Flash Nano Precipitation,FNP)法制备出一系列包裹模型药物β-胡萝卜素的纳米粒子。通过改变两亲性共聚物的结构、分子量、浓度及溶剂体积比(V(H2O):V(THF)),成功实现了对纳米粒子尺寸的调控。实验结果表明:聚合物亲水链段分子量比例增大,则纳米粒子尺寸减小;当亲水链段分子量比例相同时,聚合物分子量越大,则纳米粒子尺寸越小;当聚合物质量浓度较高(10.0 g/L)时,制备的纳米粒子粒径分布较窄,粒子性能较稳定。

       

      Abstract: Five amphiphilic diblock copolymers,methoxy poly(ethylene glycol)-b-polycaprolactone (mPEG-b-PCL) with different molecular weights and hydrophilic/hydrophobic proportions were synthesized.A series of nano particles encapsulated model drug beta-carotene and protected by the prepared copolymers as surfactants were prepared by using flash nano-precipitation (FNP) method.The size and size distribution of nano particles were controllable by changing the block structure,molecular weight,polymer concentration and solvent ratio (V(H2O):V(THF)).Experimental results showed that the size of nano particles decreased by increasing the solvent ratio or hydrophilic proportion.Under the same proportion of the hydrophilic moieties,the size of particles was decreased by increasing the molecular weight.The nano particles became more stable and their size distribution was narrower upon increasing polymer concentrations.

       

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