高级检索

  • ISSN 1006-3080
  • CN 31-1691/TQ

基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子

马俊 李莉 王铭纬 周志明 郭旭虹

马俊, 李莉, 王铭纬, 周志明, 郭旭虹. 基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子[J]. 华东理工大学学报(自然科学版), 2017, (5): 597-605. doi: 10.14135/j.cnki.1006-3080.2017.05.001
引用本文: 马俊, 李莉, 王铭纬, 周志明, 郭旭虹. 基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子[J]. 华东理工大学学报(自然科学版), 2017, (5): 597-605. doi: 10.14135/j.cnki.1006-3080.2017.05.001
MA Jun, LI Li, WANG Ming-wei, ZHOU Zhi-ming, GUO Xu-hong. Preparation of Size-Controllable Drug Loaded Nano Particles Based on Flash Nano Precipitation Method[J]. Journal of East China University of Science and Technology, 2017, (5): 597-605. doi: 10.14135/j.cnki.1006-3080.2017.05.001
Citation: MA Jun, LI Li, WANG Ming-wei, ZHOU Zhi-ming, GUO Xu-hong. Preparation of Size-Controllable Drug Loaded Nano Particles Based on Flash Nano Precipitation Method[J]. Journal of East China University of Science and Technology, 2017, (5): 597-605. doi: 10.14135/j.cnki.1006-3080.2017.05.001

基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子

doi: 10.14135/j.cnki.1006-3080.2017.05.001
基金项目: 

国家自然科学基金(21476143)

Preparation of Size-Controllable Drug Loaded Nano Particles Based on Flash Nano Precipitation Method

  • 摘要: 合成了5种具有不同分子量、不同亲疏水链段比例的两亲性嵌段共聚物——甲氧基聚乙二醇-b-聚己内酯(mPEG-b-PCL),并以其为表面活性剂,采用瞬时纳米沉淀(Flash Nano Precipitation,FNP)法制备出一系列包裹模型药物β-胡萝卜素的纳米粒子。通过改变两亲性共聚物的结构、分子量、浓度及溶剂体积比(V(H2O):V(THF)),成功实现了对纳米粒子尺寸的调控。实验结果表明:聚合物亲水链段分子量比例增大,则纳米粒子尺寸减小;当亲水链段分子量比例相同时,聚合物分子量越大,则纳米粒子尺寸越小;当聚合物质量浓度较高(10.0 g/L)时,制备的纳米粒子粒径分布较窄,粒子性能较稳定。

     

  • [1] JOHNSON B K,PRUD'HOMME R K.Mechanism for rapid self-assembly of block copolymer nanoparticles[J].Physical Review Letters,2003,91(11):1-4.
    [2] JOHNSON B K,PRUD'HOMME R K.Chemical processing and micromixing in confined impinging jets[J].AIChE Journal,2003,49(9):2264-2282.
    [3] LIU Ying,CHEN Chungyin.Mixing in a multi-inlet vortex mixer (MIVM) for flash nano-precipitation[J].Chemical Engineering Science,2008,63(11):2829-2842.
    [4] RUSS B,LIU Ying,PRUD'HOMME R K.Optimized descriptive model for micromixing in a vortex miner[J].Chemical Engineering Communications,2010,197(8):1068-1075.
    [5] BLANAZS A,ARMES S P,RYAN A J.Self-assembled block copolymer aggregates:From micelles to vesicles and their biological applications[J].Macromolecular Rapid Communications,2009,30(4/5):267-277.
    [6] SUN Huanli,GUO Bingnan,LI Xiaoqing,et al.Shell-sheddable micelles based on dextran-SS-poly(ε-caprolactone) diblock copolymer for efficient intracellular release of doxorubicin[J].Biomacromolecules,2010,11(4):848-854.
    [7] ZHULINA E B,ADAM M,LARUE I,et al.Diblock copolymer micelles in a dilute solution[J].Macromolecules,2005,38(12):5330-5351.
    [8] AATHIMANIKANDAN S V,SAVARIAR E N,THAYUMANAVAN S.Temperature-sensitive dendritic micelles[J].Journal of American Chemical Society,2005,127(42):14922-14929.
    [9] JI Yongqiang,WANG Weishan,LI Ganzuo,et al.Rheological properties of wormlike micelles formed in the sodium oleate/trisodium phosphate aqueous solution[J].Chinese Chemical Letters,2008,19(4):483-487.
    [10] MILLER T,COLEN G Van,SANDER B,et al.Drug loading of polymeric micelles[J].Pharmaceutical Research,2013,30(2):584-595.
    [11] MATSUOKA K,TAKAGI K,HONDA C.Micelle formation of sodiumhyodeoxycholate[J].Chemistry and Physics of Lipids,2013,172/173(3):6-13.
    [12] GINDY M E,PRUD'HOMME R K.Multifunctional nanoparticles for imaging,delivery and targeting in cancer therapy[J].Expert Opinion Drug Delivey,2009,6(8):865-878.
    [13] WANG Mingwei,XU Yisheng,WANNG Jie,et al.Biocompatible nanoparticle based on dextran-b-poly(L-lactide) block copolymer formed by flash nanoprecipitation[J].Chemistry Letters,2015,44(12):1688-1690.
    [14] WANG Mingwei,YANG Nan,GUO Zhiqian,et al.Facile preparation of AIE-active fluorescent nanoparticles through flash nanoprecipitation[J].Industrial & Engineering Chemistry Research,2015,54(17):4683-4688.
    [15] AKBULUT M,GINART P,GINDY M E,et al.Generic method of preparing multifunctional fluorescent nanoparticles using flash nano precipitation[J].Advanced Functional Materials,2009,19(5):718-725.
    [16] GINDY M E,PANAGIOTOPOULOS A Z,PRUD'HOMME R K.Composite block copolymer stabilized nanoparticles:Simultaneous encapsulation of organic actives and inorganic nanostructures[J].Langmuir,2008,24(1):83-90.
    [17] ADDIO D,PRUD'HOMME R K.Controlling drug nanoparticle formation by rapid precipitation[J].Advanced Drug Delivery Reviews,2011,63(6):417-426.
    [18] LIU Ying,TONG Zhen,PRUD'HOMME R K.Stabilized polymeric nanoparticles for controlled and efficient release of bifenthrin[J].Pest Management Science,2008,64(8):808-812.
    [19] ZHU Zhengxi.Effects of amphiphilic diblock copolymer on drug nanoparticle formation and stability[J].Biomaterials,2013,34(38):10238-10248.
    [20] GOU Maling,ZHENG Xiuling.Self-assembled hydrophobic honokiol loaded mPEG-PCL diblock copolymer micelles[J].Pharmaceutical Research,2009,26(9):2164-2173.
    [21] SHEN Yang,LENG Mengtian,YU Hongchi,et al.Effect of amphiphilic PCL-PEG nano-micelles on HepG2 cell migration[J].Macromolecular Bioscience,2015,15(3):372-384.
    [22] PENG Wei,JIANG Xinyi,ZHU Yuan,et al.Oral delivery of capsaicin using mPEG-PCL nanoparticles[J].Acta Pharmacologica Sinica,2015,36(1):139-148.
    [23] WANG Qin,JIANG Jiayu,CHEN Wenfei,et al.Targeted delivery of low-dose dexamethasone using PCL-PEG micelles for effective treatment of rheumatoid arthritis[J].Journal of Controlled Release,2016,230:64-72.
    [24] LINCE F,MARCHISIO D L,BARRESI A A.Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications[J].Journal of Colloid and Interface Science,2008,322(2):505-515.
    [25] HWANG Minji,SUH Ju myung,BAE You han,et al.Caprolactonic poloxamer analog:PEG-PCL-PEG[J].Biomacromolecules,2005,6(2):885-890.
    [26] SHANNIGRAHI M,BAGCHI S.Novel fluorescent probe as aggregation predictor and micro-polarity reporter for micelles and mixed micelles[J].Spectrochimica Acta:Part A.Molecular and Biomolecular Spectroscopy,2005,61(9):2131-2138.
  • 加载中
图(1)
计量
  • 文章访问数:  9027
  • HTML全文浏览量:  732
  • PDF下载量:  2001
  • 被引次数: 0
出版历程
  • 收稿日期:  2017-01-10
  • 刊出日期:  2017-10-28

目录

    /

    返回文章
    返回