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基于三(2-氨基乙基)胺和6-羧基荧光素的双模式核磁共振成像造影剂

    通讯作者: 胡爱国, hagmhsn@ecust.edu.cn
  • 基金项目: 国家自然科学基金(21274042)

  • 中图分类号: O621.3

Synthesis of Bimodal Magnetic Resonance Imaging Contrast Agent from Tris(2-aminoethyl)amine and 6-Carboxy-Fluorescein

    Corresponding author: HU Ai-guo, hagmhsn@ecust.edu.cn
  • CLC number: O621.3

  • 摘要: 通过将三(2-氨基乙基)胺(TREN)、6-羧基荧光素与溴乙酸苄酯结合而合成出多胺多羧型配体,并赋予化合物荧光成像的功能。进一步与顺磁性的六水合氯化钆(Ⅲ)反应获得兼具核磁共振成像(Magnetic Resonance Imaging,MRI)和光学成像功能的双模式核磁共振成像造影剂。通过核磁氢谱、碳谱、高分辨质谱和ICP-AES表征了配体和金属配合物的结构。研究结果表明,该配合物的纵向弛豫率(r1)为3.46 mM-1·s-1,与小分子型商用造影剂如马根维显®(Gd-DTPA)接近。该配合物同时拥有66%的荧光量子产率,在紫外光照射下显示明亮的绿色荧光,为以后进行生物体内研究打下坚实基础。
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出版历程
  • 收稿日期:  2016-04-01
  • 刊出日期:  2017-01-06

基于三(2-氨基乙基)胺和6-羧基荧光素的双模式核磁共振成像造影剂

    通讯作者: 胡爱国, hagmhsn@ecust.edu.cn
  • 1. 华东理工大学材料科学与工程学院, 上海市先进聚合物材料重点实验室, 上海 200237
基金项目:  国家自然科学基金(21274042)

摘要: 通过将三(2-氨基乙基)胺(TREN)、6-羧基荧光素与溴乙酸苄酯结合而合成出多胺多羧型配体,并赋予化合物荧光成像的功能。进一步与顺磁性的六水合氯化钆(Ⅲ)反应获得兼具核磁共振成像(Magnetic Resonance Imaging,MRI)和光学成像功能的双模式核磁共振成像造影剂。通过核磁氢谱、碳谱、高分辨质谱和ICP-AES表征了配体和金属配合物的结构。研究结果表明,该配合物的纵向弛豫率(r1)为3.46 mM-1·s-1,与小分子型商用造影剂如马根维显®(Gd-DTPA)接近。该配合物同时拥有66%的荧光量子产率,在紫外光照射下显示明亮的绿色荧光,为以后进行生物体内研究打下坚实基础。

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