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一类具有高水合常数的钆类核磁共振成像造影剂的研究

    通讯作者: 胡爱国, hagmhsn@ecust.edu.cn
  • 基金项目: 国家自然科学基金(21274042)

  • 中图分类号: O621.3

A New Type of Magnetic Resonance Imaging Contrast Agents with High Hydration Numbers

    Corresponding author: HU Ai-guo, hagmhsn@ecust.edu.cn
  • CLC number: O621.3

  • 摘要: 合成了一类具有高水合常数(q)的钆类造影剂,该类配合物由金属钆与含有2个氮氧化基团和4个羧酸基团的有机配体组成,具有高水合常数的特点。通过核磁氢谱、碳谱以及高分辨质谱对配体及配合物的结构进行了表征。通过荧光寿命分析检测配合物的q值在3左右。该类配合物的纵向弛豫率(r1)为8.5~10.1 (mM)-1·s-1,约为商用造影剂二乙三胺五乙酸合钆(Gd-DTPA)的3倍。细胞实验证实该类造影剂具有很低的细胞毒性,这在临床应用中是非常关键的。该类配合物具有合成简便、弛豫率高以及毒性低等特点,为制备更低成本、更高性能的造影剂打下基础。
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出版历程
  • 收稿日期:  2015-05-05
  • 刊出日期:  2016-02-29

一类具有高水合常数的钆类核磁共振成像造影剂的研究

    通讯作者: 胡爱国, hagmhsn@ecust.edu.cn
  • 1. 华东理工大学材料科学与工程学院, 上海市先进聚合物材料重点实验室, 上海 200237
基金项目:  国家自然科学基金(21274042)

摘要: 合成了一类具有高水合常数(q)的钆类造影剂,该类配合物由金属钆与含有2个氮氧化基团和4个羧酸基团的有机配体组成,具有高水合常数的特点。通过核磁氢谱、碳谱以及高分辨质谱对配体及配合物的结构进行了表征。通过荧光寿命分析检测配合物的q值在3左右。该类配合物的纵向弛豫率(r1)为8.5~10.1 (mM)-1·s-1,约为商用造影剂二乙三胺五乙酸合钆(Gd-DTPA)的3倍。细胞实验证实该类造影剂具有很低的细胞毒性,这在临床应用中是非常关键的。该类配合物具有合成简便、弛豫率高以及毒性低等特点,为制备更低成本、更高性能的造影剂打下基础。

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