-
图 1 克拉维酸分子结构式
Figure 1. Clavulanic acid molecular structure formula
-
图 2 带一个挡板3L摇瓶
Figure 2. 3L Flask with one baffle
-
图 3 摇瓶运动过程中药瓶内发酵液流体微元受力分析
Figure 3. Analysis of the fluid micro-element force in the fermentation liquid of the medicine bottle during shake flask movement
-
图 4 摇床运动原理示意图
Figure 4. Schematic diagram of shaker movement principle
-
图 5 利用本文提出的旋转离心加速度模型模拟得到的不同时刻形成的气液流动自由表面（80 r/min）
Figure 5. The gas-liquid flow free surface (80 r/min), which is formed at different times, is simulated by the rotational centrifugal acceleration model proposed in this paper
-
图 6 不同转速下带档板与不带挡板摇瓶中传质参数流场预测值对比（装液量680 mL）
Figure 6. Comparison of flow field prediction values of mass transfer parameters between shaker flask with and without baffle at different speeds (liquid volume 680 mL)
-
图 7 不同转速下带档板和不带挡板摇瓶形成的气液自由表面对比
Figure 7. Comparison of gas-liquid free surface formed by shaking flask with and without baffle at different rotating speed
-
图 8 带档板摇瓶中不同装液量下流场参数CFD模拟预测值（摇床转速120 r/min）（a）气液交界面面积；（b）气液比表面积；（c）平均液膜传质系数；（d）体积气液传质系数平均值
Figure 8. CFD simulation prediction value of flow field parameters under different liquid loading in shaking flask with gear plate (rotating speed of shaking table 120 r/min) (a) Gas-liquid interface area; (b) Gas-liquid specific surface area; (c) Average liquid membrane mass transfer coefficient; (d) Volume gas-liquid mass transfer coefficient average
-
图 9 带档板与不带挡板摇瓶中种子培养过程参数变化对比
Figure 9. Comparison of seed culture parameters in shaking flask with and without baffle
-
图 10 带档板与不带挡板摇瓶中装液量对克拉维酸的影响
Figure 10. Effect of liquid content in shaking flask with and without baffle on clavulanic acid
-
Roatation speed/(r·min−1) Average SSR/s−1 Relative difference/% Baffled Unbaffled 40 2.75 2.70 2 80 22.48 16.63 35 120 40.00 30.93 29 160 60.18 51.09 18 表 1 不同转速下带档板与不带档板摇瓶中平均剪切应变率（SSR）大小对比
Table 1. Comparison of average shear strain rate (SSR) in shaker with and without shaker at different rotational speeds
图共
10 个 表共
1 个
