丹酚酸B-聚氰基丙烯酸正丁酯纳米粒的制备及其体外评价

倪力军; 杨亚妮; 程晓亮; 张立国

丹酚酸B-聚氰基丙烯酸正丁酯纳米粒的制备及其体外评价

Preparation of Salvianolic Acid B Poly(butylcyanoacrylate) Nano-Particles and Evaluation of Their in vitro Properties

摘要

摘要: 用乳化聚合法制备丹酚酸B聚氰基丙烯酸正丁酯纳米粒（Sal B-PBCA NP），以吐温80和PEG 20000制备了Sal B-PBCA NP的两种包衣产物T1P0、T1P1，并考察其体外释药特性。结果表明:Sal B-PBCA NP纳米粒平均粒径99.2 nm，包封率为46.55%，载药量0.792%；Sal B-PBCA NP、T1P0、T1P1在48 h后分别累积释放（76.15±0.69）%、（63.72±1.80）%、（47.09±5.72）%；体外释药结果均符合Weibull方程。与未包衣的Sal B-PBCA NP相比，以吐温80和PEG 20000包衣的T1P1具有明显的缓释作用。

Abstract: Salvianolic acid B poly(butylcyanoacrylate) nanoparticles（Sal BPBCA NP） were prepared by emulsion polymerization method. Two formulations, T1P0 and T1P1, were prepared by coating surface of Sal B-PBCA NP using Tween 80 and PEG 20000. Drug release profiles from different formulations of Sal B-PBCANP, T1P0, T1P1 were determined. Results indicate that mean diameter, entrapment efficiency and drug loading of Sal BPBCA NP were 99.02 nm, 46.55% and 0.792%, respectively. It was found that the in vitro release of Sal BPBCA NP, T1P0 and T1P1 were accumulated up to (76.15±0.69)%, (63.72±1.80)% and (47.09±5.72)% over 48 h, respectively. The in vitro release properties could be expressed by the Weibull equation. Compared with Sal BPBCA NP without surface coating, formulation T1P1 obtained by coating surface of Sal B-PBCA NP using Tween 80 and PEG 20000 showed significant sustained release effect.

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