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    李荣梅, 赵秀雅, 张关永. (2S,3S)-N-苄氧羰基-4-苯基-3-氨基-1-氯-2-丁醇的合成与结构表征[J]. 华东理工大学学报（自然科学版）, 2006, (11): 1306-1309.
    引用本文: 李荣梅, 赵秀雅, 张关永. (2S,3S)-N-苄氧羰基-4-苯基-3-氨基-1-氯-2-丁醇的合成与结构表征[J]. 华东理工大学学报（自然科学版）, 2006, (11): 1306-1309.
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    LI Rong-mei, ZHAO Xiu-ya, ZHANG Guan-yong. Synthesis and Structural Characterization of (2S, 3S )-N-Cbz-3-Amino-1-Chloro-4-Phenyl-2-Butanol[J]. Journal of East China University of Science and Technology, 2006, (11): 1306-1309.
    Citation: LI Rong-mei, ZHAO Xiu-ya, ZHANG Guan-yong. Synthesis and Structural Characterization of (2S, 3S )-N-Cbz-3-Amino-1-Chloro-4-Phenyl-2-Butanol[J]. Journal of East China University of Science and Technology, 2006, (11): 1306-1309.
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    (2S,3S)-N-苄氧羰基-4-苯基-3-氨基-1-氯-2-丁醇的合成与结构表征

    Synthesis and Structural Characterization of (2S, 3S )-N-Cbz-3-Amino-1-Chloro-4-Phenyl-2-Butanol

      摘要
    • 摘要: 以天然产物中提取的L-苯丙氨酸为原料,经氨基保护、重氮化反应、氯化和还原反应后合成了(2S,3S)-N-苄氧羰基-4-苯基-3-氨基-1-氯-2-丁醇。并以高效液相色谱-质谱联用技术、单晶X射线衍射等方法对产品进行了分析和结构表征。

       

      Abstract: (2S,3S)-N-Cbz-3-amino-1-chloro-4-phenyl-2-butanol is an important intermediate for the synthesis of HIV protease inhibitors.Using natural L-phenylalanine(L-Phe) as starting material, through amino protection,Arndt-Eistert reaction,chlorination and reduction,(2S,3S)-N-Cbz-3-amino-1-chloro-4-phenyl-2-butanol was obtained,and characterized by LC-MS and X-ray diffraction.

       

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