Abstract: In this paper, the removal of trace metal ions in isopropanol was studied. Since the factory ion exchange resin is sodium type, the sodium type ion exchange resin is first subjected to acid treatment, alkali treatment and acid treatment to convert it into a hydrogen type. Then, the isothermal adsorption data and kinetic data of Na⁺ and K⁺ in isopropanol were obtained by static adsorption experiments of ion exchange resin. The isothermal adsorption obtained by origin fitting conforms to the langmuir isothermal adsorption model, and the kinetics conforms to the pseudo-first-order kinetic model. Then, the maximum adsorption capacities of Na⁺ and K⁺ in isopropanol were 4.28 mg/g and 3.36 mg/g, respectively. The breakthrough curves of Na⁺ and K⁺ were obtained by dynamic experiments. The adsorption process was assumed, and an adsorption physical model ignoring pressure drop and temperature change was established. The dynamic adsorption process of Na⁺ and K⁺ in isopropanol was simulated by Aspen Adsorption, and the simulation results were in good agreement with the experimental breakthrough curves. The metal ions in isopropanol were removed by ion exchange resin, and the content of metal ions in isopropanol was less than 5 μg/L. These results provide a basis for the design of adsorption device for trace metal ions in isopropanol. At the same time, a method of slowly digesting the resin with nitric acid and hydrogen peroxide in a heated environment was proposed. This method can detect the content of metal ions in the styrene resin, and the error between the detection result and the actual value is less than 10%.