Abstract: Using metal-organic framework (UIO-66) as the support,two supported catalysts Au@UIO-66 and Pd@UIO-66 were prepared by impregnation reduction method and characterized by transmission electron microscope (TEM),X-ray diffraction (XRD),infrared spectroscopy (IR) and N₂ adsorption-desorption.The results showed that gold nanoparticles with size of 13 nm were uniformly dispersed on the carrier and the nano-palladiums also dispersed uniformly on UIO-66 as 5-8 nm nanoparticles and nanowires.The catalytic performance of two catalysts in the catalytic reduction of p-nitrophenol under different conditions was studied.Both catalysts had high catalytic activity.When 10 mg catalyst was used in 100 mL p-nitrophenol aqueous solution (1.6×10^-4 mol/L),the conversion of p-nitrophenol can reach more than 95% within 5 min.