维A酸自微乳给药系统制备与体外评价

Preparation and Evaluation of Retinoic Acid Selfmicroemusifying Drug Delivery System

摘要: 制备了维A酸自微乳给药系统(ATRASMEDDS)并进行体外评价。根据伪三元相图，选择Cremorphor RH40(RH40）和吐温20（T20）作为复配乳化剂，以微乳形成后的粒径和乳化时间为评价指标筛选处方。当m(RH40)∶m(T20)=1∶1时，制得的微乳粒径为(25.8±3.0)nm，ATRASMEDDS在不同介质中的溶出度均显著提高，有望提高其生物利用度。关键词：维A酸；自微乳化给药系统；乳化剂；溶出度

Abstract: Retinoic acid selfmicroemusifying drug delivery system (SMEDDS) was developed and evaluated. According to the pseudoternary diagram, Cremorphor RH40(RH40) and Tween 20(T20) were selected as emulsifiers. The formulations were screened by droplet size of microemulsion generated upon dilution and emulsification time. The droplet size of microemulsion was (25.8±3.0)nm when m(RH40)∶m(T20) was 1∶1. The dissolution profiles of retinoic acid in different mediums were significantly improved in SMEDDS, which is advantageous to improve oral bioavailability of retinoic acid.