Abstract:
A novel side chain dendronized polyhydric polyurethane was synthesized by sequential conjugation of amine
-terminated fourth generation polyester dendrons with pendent carboxyl groups of polyurethane and deprotection of
acetonide groups at the surface of dendrons. The polyurethane base polymer was synthesized using PCDL as soft
segments, HDI as hard segments, and bis-MPA as chain extenders. The polyhydric polyurethane was used to immobilize
CD133 antibody by hydrogen bonding. Endothelial progenitor cells (EPC) attachment was significantly enhanced on the
surfaces of the CD133 antibody immobilized polyurethane, which may be contribute to improve the hamoecompatibility
of the blood contacting materials by quick endothelialization.