离子交联法制备氟尿嘧啶壳聚糖微球

Preparation of FluorouracilLoaded Chitosan Microspheres Using Ion Crosslinking Technique

摘要: 以壳聚糖为药用载体，5氟尿嘧啶为模型药物，三聚磷酸钠为离子交联剂，采用离子交联法制备壳聚糖微球制剂，考察处方和工艺因素对载药微球形态、包封率及体外释放行为的影响；采用扫描电镜、粒度分析仪和红外光谱对微球结构进行表征。结果表明：5氟尿嘧啶壳聚糖微球的包封率可达到77.8%，平均粒径为6.4 μm，30 min时体外突释为21.3%，48 h以内的累积释药率为77.0%，缓释作用明显。

Abstract: 5Fluorouracilloaded chitosan microspheres were prepared by ion crosslinking technique using chitosan as drug carrier and sodium tripolyphosphate as crosslinker reagent. The morphous of microspheres，the encapsulation efficiency and in vitro release behavior were used to evaluate the influence of different formulations and preparations. The structure of the microspheres was analyzed using scanning electron microscopy, granulometer and infrared spectrum. The results showed that the encapsulation efficiency of 5fluorouracilloaded chitosan microspheres was 77.8%. The mean diameter was 6.4 μm, and the initial burst release was 21.3% at 30 min, and the cumulative release was 77.0% within 48 h. The sustained drug release effect was notable in vitro.