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    苏熠东, 吴范宏. 8-氯-10,11-二氢-4-氮杂-5H-二苯并[a,d]-5-环庚酮的合成[J]. 华东理工大学学报（自然科学版）, 2002, (6): 665-667.
    引用本文: 苏熠东, 吴范宏. 8-氯-10,11-二氢-4-氮杂-5H-二苯并[a,d]-5-环庚酮的合成[J]. 华东理工大学学报（自然科学版）, 2002, (6): 665-667.
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    SU Yi-dong, WU Fan-hong *. Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d] cyclohepten-5-one[J]. Journal of East China University of Science and Technology, 2002, (6): 665-667.
    Citation: SU Yi-dong, WU Fan-hong *. Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d] cyclohepten-5-one[J]. Journal of East China University of Science and Technology, 2002, (6): 665-667.
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    8-氯-10,11-二氢-4-氮杂-5H-二苯并a,d-5-环庚酮的合成

    Synthesis of 8-Chloro-10,11-dihydro-4-aza-5H-dibenzoa,d cyclohepten-5-one

      摘要
    • 摘要: 以2-氰基-3-甲基吡啶为原料，通过Ritter反应、烷基化、腈化、水解、环化等五步反应成了氯雷他定的重要中间体8-氯-10，11-二氢杂-5H-二苯并a,d-5-环庚酮，总收率为25.6%，其结构经核磁共振、质谱等确证。

       

      Abstract: Chloro-10,11-dihydro-4-aza-5H-dibenzoa,dcyclohepten-5-one is an important intermediate of loratadine.It was synthesized from 2-cyano-3-methylpyridine as the starting material via Ritter reaction, alkylation, cyanidation, hydrolysis and cyclization under mild conditions. The total yield attained was 25.6%. The chemical structure was confirmed by means of 1 H-NMR,MS and m.p.data.

       

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