Abstract: Based on the onedimensional pseudohomogenous mathematical model, the adiabatic multibed reactor with indirect heat exchange for MethanoltoOlefin (MTO) reaction was simulated. Target for the 3×105 t/a ethylene yield, the volume of the catalytic bed and mass of the catalyst needed were calculated. The profile of temperature and distribution of the reaction components in the reactor was analyzed, and the heat balance in the indirect heat exchange sections was calculated.