盐酸西替利嗪的改进合成
Improved Synthesis of Cetirizine Hydrochloride
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摘要: 对氯卞氯和苯经付克反应,光溴化,得到4-氯二苯基溴甲烷,然后经与羟乙基哌嗪缩合、与氯乙酸钠反应、加盐酸成盐、精制得西替利嗪盐酸盐,总收率为29%。Abstract: Chlorodiphenylbromomethane, prepared by the bromination following the Friedel-Crafts reaction of benzene with p-chlorobenzyl chloride, underwent the reaction sequences of two condensations, and salt formation with hydrochloric acid to obtain cetirizine hydrochloride with an overall yield of 29%.