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    王健君, 杨雪艳, 吴范宏. 盐酸西替利嗪的改进合成[J]. 华东理工大学学报(自然科学版), 2002, (6): 668-670.
    引用本文: 王健君, 杨雪艳, 吴范宏. 盐酸西替利嗪的改进合成[J]. 华东理工大学学报(自然科学版), 2002, (6): 668-670.
    WANG Jian-jun, YANG Xue-yan, WU Fan-hong *. Improved Synthesis of Cetirizine Hydrochloride[J]. Journal of East China University of Science and Technology, 2002, (6): 668-670.
    Citation: WANG Jian-jun, YANG Xue-yan, WU Fan-hong *. Improved Synthesis of Cetirizine Hydrochloride[J]. Journal of East China University of Science and Technology, 2002, (6): 668-670.

    盐酸西替利嗪的改进合成

    Improved Synthesis of Cetirizine Hydrochloride

    • 摘要: 对氯卞氯和苯经付克反应,光溴化,得到4-氯二苯基溴甲烷,然后经与羟乙基哌嗪缩合、与氯乙酸钠反应、加盐酸成盐、精制得西替利嗪盐酸盐,总收率为29%。

       

      Abstract: Chlorodiphenylbromomethane, prepared by the bromination following the Friedel-Crafts reaction of benzene with p-chlorobenzyl chloride, underwent the reaction sequences of two condensations, and salt formation with hydrochloric acid to obtain cetirizine hydrochloride with an overall yield of 29%.

       

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