Abstract: Strong acid cation exchange resin was utilized as a kind of catalyst to synthesize triacetonamine. The influence of both reaction pressure and temperature on the yield of triacetonamine was investigated. Moreover, the catalytic activity of resin supported different cations by ion exchange was studied in detail. Comparing with other solid acids such as alumina, weak acid cation exchange resin, montmorillonite K10 and 3A molecular sieve, FeCl3 modified strong acid cation exchange resin had the highest catalytic activity and the yield of triacetonamine was up to 26%. The modified catalyst was analyzed by UVVis spectroscopy and Fourier transform infrared spectroscopy. After it was reused six times, this catalyst showed a relative high catalytic activity yet.