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    陆欣宇, 王慧辰, 朱为宏. 合成邻甲氧基肉桂酸的两步法新工艺[J]. 华东理工大学学报(自然科学版), 2014, (1): 70-73.
    引用本文: 陆欣宇, 王慧辰, 朱为宏. 合成邻甲氧基肉桂酸的两步法新工艺[J]. 华东理工大学学报(自然科学版), 2014, (1): 70-73.
    LU Xin-yu, WANG Hui-chen, ZHU Wei-hong. Novel Two Step Synthesis of o Methoxycinnamic Acid[J]. Journal of East China University of Science and Technology, 2014, (1): 70-73.
    Citation: LU Xin-yu, WANG Hui-chen, ZHU Wei-hong. Novel Two Step Synthesis of o Methoxycinnamic Acid[J]. Journal of East China University of Science and Technology, 2014, (1): 70-73.

    合成邻甲氧基肉桂酸的两步法新工艺

    Novel Two Step Synthesis of o Methoxycinnamic Acid

    • 摘要: 以邻甲氧基苯甲醛(OMD)为原料,与丙酮进行Claisen Schmidt缩合反应形成中间体邻甲氧基苄叉丙酮(OMT),OMT再与NaClO发生卤仿反应得到邻甲氧基肉桂酸(OMA)。优选的工艺条件是:缩合反应中丙酮与OMD的物质的量之比为2.5,反应温度为20~30 ℃,反应时间为6 h;卤仿反应温度为20~30 ℃,反应时间为8 h。经φ=30%乙醇水溶液重结晶后,OMA的总收率按OMD计为81%,气相色谱测得OMA纯度为99.2%。

       

      Abstract: Abstract: o Methoxycinnamic acid(OMA) was prepared by Claisen Schmidt condensation of o methoxybenzaldehyde(OMD) with acetone and then by Lieben haloform reaction of the intermediate o methoxybenzalacetone(OMT) with NaClO. Acetone and OMD were condensed with a molar ratio of 2.5 at 20—30 °C for 6 h to obtain crude OMT, which was used directly in haloform reaction at 20—30 °C for 8 h to obtain OMA with a total yield of 81% after recrystallization from φ=30% ethanol solution(GC purity 99.2%).

       

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