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    耿娓琴, 陈钟瑛, 严秉淳. 芳姜黄酮和姜烯衍生物的合成及抗生育活性初探[J]. 华东理工大学学报(自然科学版), 1990, (1).
    引用本文: 耿娓琴, 陈钟瑛, 严秉淳. 芳姜黄酮和姜烯衍生物的合成及抗生育活性初探[J]. 华东理工大学学报(自然科学版), 1990, (1).
    Synthesis of Sesquiterpene Ar-Turmerone and Optically Active Zingiberene Derivatives and Exploration of Their Antifertility Effect[J]. Journal of East China University of Science and Technology, 1990, (1).
    Citation: Synthesis of Sesquiterpene Ar-Turmerone and Optically Active Zingiberene Derivatives and Exploration of Their Antifertility Effect[J]. Journal of East China University of Science and Technology, 1990, (1).

    芳姜黄酮和姜烯衍生物的合成及抗生育活性初探

    Synthesis of Sesquiterpene Ar-Turmerone and Optically Active Zingiberene Derivatives and Exploration of Their Antifertility Effect

    • 摘要: 叙述了四个倍半萜类衍生物——芳姜黄酮(Ⅰ)、对甲氧基芳姜黄酮(Ⅱ)、(-)-异丙水芹烯(Ⅲ)、(-)-水芹烯羧酸乙酯(Ⅳ)的合成及结构确证。(Ⅱ~Ⅳ)未见文献报道。初步药理筛选结果表明:(Ⅰ)抗生育活性不理想;(Ⅲ)具有一定的抗生育活性。

       

      Abstract: The synthesis of four compounds, viz., ar-turmerone, (-)-isopropyl phellandrene, (-)-ethoxy carbonyl phellandrene and methoxy ar-turmerone, and the identification of their chemical structures are described. The preliminary pharmacological test data indicate that the antifertility effect of ar-turmerone is unsatisfactory and (-)-isopropyl phellandrene is antifertilely effective to a certain extent. The antifertility effect of (-)-ethoxy carbonyl phellandrene and methoxy ar-turmerone is being assayed.As far as authors know, the compounds of (-)-isopropyl phellandrene, (-)-ethoxy carbonyl phellandrene and methoxy ar-turmerone have not been reported in the literature.

       

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