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    汪灵, 刘黎, 汤亭亭, 郭圣荣. 壳聚糖季铵盐的合成及其抗菌膜的研究[J]. 华东理工大学学报(自然科学版), 2009, (3): 390-395.
    引用本文: 汪灵, 刘黎, 汤亭亭, 郭圣荣. 壳聚糖季铵盐的合成及其抗菌膜的研究[J]. 华东理工大学学报(自然科学版), 2009, (3): 390-395.
    Synthesis of Hydroxypropyltrimethyl Ammonium Chloride Chitosan and Study on Their Antibacterial Films[J]. Journal of East China University of Science and Technology, 2009, (3): 390-395.
    Citation: Synthesis of Hydroxypropyltrimethyl Ammonium Chloride Chitosan and Study on Their Antibacterial Films[J]. Journal of East China University of Science and Technology, 2009, (3): 390-395.

    壳聚糖季铵盐的合成及其抗菌膜的研究

    Synthesis of Hydroxypropyltrimethyl Ammonium Chloride Chitosan and Study on Their Antibacterial Films

    • 摘要: 用壳聚糖和2,3-环氧丙基三甲基氯化铵合成了3种不同取代度(DS:37.3%,56.0%,81.5%)的壳聚糖季铵盐,并用红外光谱和核磁共振对其结构进行表征;测定了所合成壳聚糖季铵盐的溶解度、稀溶液pH稳定性、吸湿性等相关性质,同时对其成膜性、膜抑菌性作了初步研究。结果表明:壳聚糖季铵盐的溶解度、稀溶液pH稳定性和吸湿性随着壳聚糖季铵盐取代度的增加而增加;壳聚糖季铵盐具有良好的成膜性,所得膜透明光滑,有一定的强度和韧性,对金黄色葡萄球菌和大肠杆菌的抑菌效果均明显优于壳聚糖膜。

       

      Abstract: Three kinds of 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) with different degrees of substitution (DS: 37.3%, 56.0%, 81.5%) were synthesized by the reaction of chitosan with glycidyltrimethylammonium chloride (GTMAC), and characterized by FT-IR and 1H-NMR spectroscopy. Their properties such as water solubility, aqueous solution stability upon pH, moisture absorption ability were determined, following with the studies of filmforming capability and the antibacterial property of films. Results indicated that the water solubility, aqueous solution stability upon pH and moisture absorption ability increased with increasing DS of HACC. Additionally, HACC films, prepared by tape casting with their dilute solutions, were presented as transparent films with favorable mechanical performance and better antibacterial property against Staphylococcus aureus and Escherichia coli than chitosan film.

       

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