Abstract: Great progress has been made in the fundamental theories and applications of chemical engineering. With the advancement of modern sciences, there emerges an interdisciplinary field termed agrochemical engineering that incorporates the knowledge and techniques of both chemical engineering and agricultural science. In this review, the conceptual advancement of agrochemical engineering and the recent progress in the preparation and application of nano-agrochemicals are described. In particular, the newly emerged preparation methods for nano-pesticides such as the flash nano-precipitation technology, the development of smart pesticides for controlled drug release, the migration trend of nano-pesticides, and the extension of new fertilizers and pesticides to the integral control of water and agrochemicals are discussed in details. Finally, a perspective is given in regard to the future development of agrochemical engineering.