Abstract: Heat exchanger is a common and crucial equipment in almost every engineering application. Energy is the foundation of economic development. The design of excellent heat transfer equipment is one of the important ways to save energy. Compared with straight heat transfer tube, spiral tube has better heat transfer performance due to the enhanced heat transfer characteristics. It is widely used in heat exchange equipments. In this paper, the structure and size of enhanced heat transfer spiral tube in industrial application were designed in order to improve the heat transfer efficiency and save energy. In the spiral tube of 500 mm length, computational fluid dynamics (CFD) was used to simulate and analyze the heat transfer performance of the ellipse spiral tube, circular spiral tube, and rotation angle spiral tube. The calculation result shows that the rotation angle spiral tube has the best heat transfer performance. For the rotary angle spiral tubes,they have five different structures with 0°, 15°, 30°, 45° and 60°, and the heat transfer performance of that with 30° is the best. On the basis of 30° rotation angle structure, different rotation angle structures with 24°, 26°, 28°, 32°, 34° and 36° were simulated. The optimal structure obtained by simulation is of 32° rotation angle. The outlet temperature of this structure is 19.50% higher than that of ellipse spiral tube, and 11.68% higher than that of 0° rotation angle spiral tube. Moreover, tubes with ellipse spiral structure, circular spiral structure and 32° rotation angle structure were simulated in pressure and velocity, and the calculation result shows that the tube with 32° rotation angle structure has the best pressure and velocity distribution, whose outlet velocity is 20.13% higher than that of ellipse spiral structure, and 16.13% higher than that of circular spiral structure. Through the optimization and simulation of the spiral tube, heat transfer efficiency and overall heat transfer performance can be improved, which provide a reference for the design of internal structure of spiral tube. These results should be instructive to the optimization of enhanced heat transfer equipment.