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线性-树枝状共聚物载药微球的制备、表征及体外释放
杨李影,郭睿,戎宗明
0
(华东理工大学化学与分子工程学院, 上海 200237;巴斯夫上海涂料有限公司, 上海 201108)
摘要:
以自制的生物可降解线性-树枝状两嵌段两亲共聚物材料为药物载体,采用透析法制备了雷帕霉素载药微球。通过扫描电子显微镜(SEM)、动态光散射仪(DLS)、紫外分光光度计对雷帕霉素载药微球的表面形貌、粒径分布、载药量及释放行为进行了研究。结果表明:载药微球的载药量和包封率分别可达到40%和90%以上,与哑铃型三嵌段两亲共聚物载药微球相当,但平均粒径大幅降低(粒径约300 nm),同样具有显著的缓释作用。
关键词:  线性-树枝状共聚物  生物可降解  载药微球  体外释放  雷帕霉素
DOI:10.14135/j.cnki.1006-3080.2017.01.008
投稿时间:2016-04-27
基金项目:
Preparation, Characterization and Release Behavior of Drug-Loaded Microparticles by Linear-Dendritic Diblock Copolymer
YANG Li-ying,GUO rui,RONG Zong-ming
(School of Chemisty and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;BASF Shanghai Coatings Co. Ltd, Shanghai 201108, China)
Abstract:
The rapamycin-loaded spherical microparticle based on biodegradable linear-dendritic diblock copolymer is prepared by dialysis method.Scanning electronic microscope(SEM),dynamic light scattering(DLS) and UV spectrophotometer were used to investigate morphology,size and in vitro release behavior of these particles.The results showed that the drug content and encapsulation efficiency of drug-loaded microparticles prepared by diblock copolymer,as well as those prepared by dumbbell-shaped triblock copolymer,could be more than 40% and 90%,respectively.Meanwhile,the mean size of those microparticles reduced significantly and it showed an obvious sustained release as well.
Key words:  linear-dendritic diblock copolymer  biodegradable  drug-loaded microparticles  drug in vitro release  rapamycin

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